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2 . 2020

Dynamics of indicators of vitamin D status in children with cystic fibrosis of the Moscow region for 2016-2018

Abstract

Vitamin D deficiency is widespread in patients with cystic fibrosis (CF). From 2016 to 2018, prophylactic doses of vitamin D were prescribed for the patients of the Russian cystic fibrosis Center in accordance with the National cystic fibrosis consensus and they were informed about the role of vitamin D deficiency.

The aim of the study was to conduct a comparative analysis of the frequency of deficiency and insufficiency of vitamin D in children with CF of different ages in Moscow region in 2016 and 2018.

Material and methods. The study involved 115 patients with CF at the age of 0-18 in 2016 and 211 children of the same age in 2018. All children underwent determination of 25(OH)D in blood serum by ELISA.

Results and discussion. The frequency of vitamin D deficiency and insufficiency [25(OH)D level <30 ng/ml] in CF patients in 2016 was 64.3%, and in 2018 - 48.7%. Among children of 0-3 years normal serum 25(OH)D levels (>30 ng/ml) were registered in 62.5% in 2016 and in 62.2% in 2018, in children of 4-11 years - 28.8% in 2016 and 58.1% in 2018, among adolescents (11-18 years) - 11.8 and 30.2%, respectively.

Conclusion. Comparative analysis showed a positive dynamics in reducing the proportion of CF patients with vitamin D deficiency and insufficiency against the background of continuous use of prophylactic doses of cholecalciferol and educational work for the period from 2016 to 2018. However, in a significant proportion of patients (48.7%), vitamin D level did not reach the norm in 2018 that requires the correction of preventive doses and increase in patient compliance.

Keywords:vitamin D, cystic fibrosis, deficiency, insufficiency, 25(OH)D, cholecalciferol, age features, season of the year

Funding. The research was supported by the Russian Foundation for Basic Research (grant No. 18-015-00482).

Conflict of interest. The authors declare no conflicts of interest.

For citation: Kondratyeva E.I., Zhekaite E.K., Odinaeva N.D., Voronkova A.Yu., Sherman V.D., Loshkova E.V., Mel'yanovskaya Yu.L., Zod'binova A.E., Shubina Yu.F., Budzinsky R.M. Dynamics of indicators of vitamin D status in children with cystic fibrosis of the Moscow region for 2016-2018. Voprosy pitaniia [Problems of Nutrition]. 2020; 89 (2): 90-9. DOI: 10.24411/0042-8833-2020-10019 (in Russian)

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CHIEF EDITOR
CHIEF EDITOR
Viktor A. Tutelyan
Full Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, Scientific Director of the Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia)

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