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Zero valent seleniumе nanoparticles bioavailability estimation in rats

AbstractBioavailability of zero valent selenium (Se) nanoparticles with average size 60 nm was measured in rats receiving selenium deficient diet. There was demonstrated that intragastric administration of Se nanoparticles resulted in dose-dependent increase of serum Se level, normalization of tissue thiol pools, immune status and hepatocytes apoptosis. Possibilities are discussed of Se nanoparticles use in nutrition as a source of this trace element.

Keywords:zero valent selenium, nanoparticles, rats, bioavailability


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