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The effect of fatty component of diet and coenzyme Q10 on rat sufficiency with vitamins-antioxidans in chronic experiments

AbstractThe full replacement of fatty component of a diet (10% of feed mass, sunflowerseed oil and lard 1:1) on enriched with α-tocopherol acetate fish oil or on linen oil under additional coenzyme Q10 intake (100 mg per 1 kg body weight) within 12 months led to a significant vitamin A blood serum decrease on 23–31%, 2–2,8 fold fall of vitamin Е blood serum level and vitamin C rat liver diminution due to significant dehydroascorbic acid reduction on 28–45%. In both cases, the intensification of POL was not observed. The use of palm-oil as a fatty component led to a significant vitamin A blood serum decrease on 31%, but didn’t effect on all other investigated parameters. The deterioration of antioxidant status indexes (MDA in blood serum and liver and diene conjugates in serum), observed after 3 months of the additional PUFA ω-3 introduction into the diet under coenzyme Q10 intake, after the 12-month use of modified diet leveled. Age increase of vitamin A blood serum concentration in rats fed diets with high PUFA ω-3 content was 2-fold higher and amounted to 68–78% compared to 31–33% in the control group of rats and rats treated with palm oil. α-Tocopherol serum content was significantly increased in all groups with increasing of rats age. 8,9 fold elevation was observed in the group of animals treated with linseed oil, and 2,5–3,2 fold in all other groups. The conclusion about the necessity of supplementary intake of vitamin E or a complex of vitamins-antioxidants under enrichment of a diet with ω-3 polyunsaturated fatty acids has been done.

Keywords:diet fatty component, vitamin A, vitamin E, vitamin C, lipid peroxidation, liver, blood serum, rat


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