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The cell immunity in patients with arterial hypertension and obesity

AbstractIn the present study the relative quantity subpopulations of lymphocytes, activated T- lymphocytes and CD95-antigen (Fas/APO-1) expression on lymphocytes in the peripheral blood of patients with arterial hypertension and obesity in comparison with the healthy persons was determined. The cells were analyzed by the method of flow cytometry using Beckman Coulter FC 500 cytometer. The following of cells subsets: CD19+, CD3+, CD3+CD4+, CD3+CD8+, CD3-CD16+СD56+, CD3+CD16+CD56+, CD3+CD25+, CD3+HLA-DR+, CD45+CD95+ were investigated. In this research was establish the rise of immunoregulatory index (CD3+CD4+/CD3+CD8+) in consequence of increase the percentages of T-helper and decrease the cytotoxic T-lymphocytes in patients with arterial hypertension and obesity in comparison with the healthy persons. In the peripheral blood of patients with arterial hypertension and obesity were observed a greater level of activated T-lymphocytes (CD3+CD25+, CD3+HLA-DR+), that reflect the increase activity of T-cell immunity. In these patients a greater level of NKT-cells (CD3+CD16+CD56+) and lymphocytes expression of CD95-antigen in comparison with the healthy persons also was noted. The direct correlation between the increased quantity of T-helper lymphocytes, activated T-lymphocytes, NKT-cells, lymphocytes expression of CD95-antigen, and index of body mass in patients with arterial hypertension and obesity was found.

Keywords:arterial hypertension, obesity, subpopulations of lymphocytes, markers of activation, cell immunity


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