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Effects of taurine supplementation on apoptosis, lipid peroxidation and proteomic pools of subcellular fractions of rats hepatic cells during ontogenesis

AbstractDuring research specific proteomic pools of subcellular fractions of rats hepatic cells typical for different states of ontogenesis were identified. Taurine supplementation during early ontogenesis leads to a production of a catalase in rats’ microsomes, that may be an evidence of activation of antioxidant defense system. Majority of proteomic markers (С-type lectin, SH2B1, protein phosphatase-1), which was investigated during taurine supplement, are rather identify features of energy homeostasis, than common assessment of apoptosis or expression certain set of proteins. This fact confirms the requirement of using proteomic diagnostic during nutriproteomic studies that allows defining efficiency and probable risks of using biological active substances in nutrition.

Keywords:taurine, proteomic, ontogenesis, apoptosis, lipid peroxidation


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